目的 合成铁杆蒿呋喃酮苷,为以后研究其抗肿瘤活性奠定基础。方法 以茴香醛为原料,通过亲核加成、亲电取代及脱水成环反应合成铁杆蒿呋喃酮苷,并运用核磁共振鉴别(NMR)法鉴定其结构式。结果 通过化学合成得到铁杆蒿呋喃酮苷,产率为53%。结论 合成铁杆蒿呋喃酮苷工艺路线简单,反应条件温和,原料易得,易于大规模制备。
Abstract
OBJECTIVE To synthesize sacroflavonoside for laying foundation for the future study of its anti-tumor activity. METHODS Sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization reaction, and its structure was identified by NMR and MS. RESULTS Sacroflavonoside was obtained by chemical synthesis and the yield was 53%. CONCLUSION The synthesis process of sacroflavonoside is simple, the reaction condition is moderate, the raw material is easy to obtain and it is easy to prepare on a large scale.
关键词
铁杆蒿呋喃酮苷 /
茴香醛 /
合成 /
核磁共振鉴别
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Key words
sacroflavonoside /
aubepin /
synthesis /
NMR identification
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中图分类号：
R914
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参考文献
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脚注
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基金
国家自然科学基金项目资助(81660698)
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